Biotech Law

Coping with complexity in metabolic engineering

Joerg Mampel, Joerg Martin Buescher, Guido Meurer, Juergen Eck. In the past decade, systems biology has revealed great metabolic and regulatory complexity even in seemingly simple microbial systems. Metabolic engineering aims to control this complexity in orde….

Anaerobic fermentation of glycerol: a platform for renewable fuels and chemicals

James M. Clomburg, Ramon Gonzalez. Highlights► Glycerol is an abundant and inexpensive carbon source generated as a by-product of biofuel production. ► High degree of reduction of glycerol enables increased yields of fuels and redu….

Single-use disposable technologies for biopharmaceutical manufacturing

Abhinav A. Shukla, Uwe Gottschalk. Highlights► Single-use disposable technologies in the manufacturing of biopharmaceuticals ► Advantages and limitations of single-use manufacturing ► Single-use systems for protein drug substance p….

Biofuels development and the policy regime

Jim C. Philp, Ken Guy, Rachael J. Ritchie. Any major change to the energy order is certain to provoke both positive and negative societal responses. The current wave of biofuels development ignited controversies that have re-shaped the thi….

Erratum: Antibacterial properties of nanoparticles

Mohammad J. Hajipour, Katharina M. Fromm, Ali Akbar Ashkarran, Dorleta Jimenez de Aberasturi, Idoia Ruiz de Larramendi, Teofilo Rojo, Vahid Serpooshan, Wolfgang J. Parak, Morteza Mahmoudi.

Haptoglobin: the hemoglobin detoxifier in plasma

Abdu I. Alayash, Christian Brix Folsted Andersen, Søren Kragh Moestrup, Leif Bülow. Hemoglobin (Hb) is one of the most studied proteins. However, oxidative toxicity associated with free Hb in circulation and its contribution to inflammation and complications of transfusion have … Continue reading

Genetic encoding of fluorescent RNA ensures a bright future for visualizing nucleic acid dynamics

Jason Dictenberg. Recently RNA localization has been appreciated as an essential post-transcriptional mechanism to program local proteome composition and function. Although RNA has been visualized using diverse tec….

Biotechnological opportunities with the β-ketoadipate pathway

Tyrone Wells, Arthur J. Ragauskas. The β-ketoadipate pathway (β-KAP) is an enzyme-mediated aryl-ring degradation sequence employed by a wide selection of soil bacteria and fungi to reconcile the conversion of many hazardous aromati….

Biosensors: then and now

Anthony Turner.

Developments in quantitative mass spectrometry for the analysis of proteome dynamics

Christopher Hughes, Jeroen Krijgsveld. Two of the primary responses in a cell when perturbed are modulation of the dynamics of its constituent gene expression and protein abundance to restore steady-state homeostasis. To obtain a detai….