Biotech Law

Microbials for the production of monoclonal antibodies and antibody fragments

Oliver Spadiut, Simona Capone, Florian Krainer, Anton Glieder, Christoph Herwig. • Glycosylated full length antibodies are currently produced in mammalian cells.• Antibody fragments can be produced in microbial organisms.• Strain engineering….

Biotechnological approaches toward nanoparticle biofunctionalization

Svetlana Avvakumova, Miriam Colombo, Paolo Tortora, Davide Prosperi. • We propose optimal functionalization of nanoparticles for enhanced cell targeting.• We discuss the challenges of controlling protein orientation on nanoparticles.

Modeling of cell sorting and rare cell capture with microfabricated biodevices

Gabor Jarvas, Andras Guttman. • We review CFD modeling of microfabricated cell sorting devices for rare cell capture.• We discuss important simulation approaches for cell sorting and rare cell ca….

Towards storage of cells and gametes in dry form

P. Loi, D. Iuso, M. Czernik, F. Zacchini, G. Ptak. • Liquid nitrogen is the current golden standard for cell and gamete preservation.• Liquid nitrogen storage is effective, but costly, and presents some practical and….

Electrochemical real-time nucleic acid amplification: towards point-of-care quantification of pathogens

Adriana S. Patterson, Kuangwen Hsieh, H. Tom Soh, Kevin W. Plaxco. • We review current methods for electrochemical real-time nucleic acid amplification.• Electrochemical detection rivals optical methods due to low cost and complexit….

Virus-like particle-based human vaccines: quality assessment based on structural and functional properties

Qinjian Zhao, Shaowei Li, Hai Yu, Ningshao Xia, Yorgo Modis. • Human vaccines against three viruses employ recombinant virus-like particles (VLPs).• VLPs are excellent vaccine antigens because they faithfully mimic the native ….

Mushroom immunomodulators: unique molecules with unlimited applications

Hesham A. El Enshasy, Rajni Hatti-Kaul. • Mushroom immunomodulators as safe alternatives to chemical drugs in medicine.• Application of mushroom immunomodulators in animal feed and aquaculture.• Mushr….

Potential of proton-pumping rhodopsins: engineering photosystems into microorganisms

Nico J. Claassens, Michael Volpers, Vitor A.P. Martins dos Santos, John van der Oost, Willem M. de Vos. • PPRs are photosystems that can be relatively easily introduced into microorganisms.• A large natural diversity of PPRs is available for different … Continue reading

Dissecting the assays to assess microbial tolerance to toxic chemicals in bioprocessing

Kyle A. Zingaro, Sergios A. Nicolaou, Eleftherios T. Papoutsakis. • Tolerance to toxic chemicals is a limiting issue in industrial bioprocesses.• Industrial practice should guide tolerance assay design.• Many parameters affect….

Synthetic biology at all scales

Arthur Prindle.