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Spider silks and their applications

Jonathan A. Kluge, Olena Rabotyagova, Gary G. Leisk, David L. Kaplan. Spider silks are characterized by remarkable diversity in their chemistry, structure and functions, ranging from orb web construction to adhesives and cocoons. These unique materials have prompted….

Microbial transformation of propenylbenzenes for natural flavour production

Ping Xu, Dongliang Hua, Cuiqing Ma. Propenylbenzenes are common aromatic compounds that are often used as starting compounds for the production of various flavours. Recently, microbial transformation has emerged as an important appr….

Engineering photorespiration in chloroplasts: a novel strategy for increasing biomass production

Muhammad Sarwar Khan. Photosynthetic carbon metabolism is rate limiting in C3 plants because of a competing process: photorespiration. Photorespiration lowers the energy efficiency of photosynthesis by metab….

Handmade cloning: the future way of nuclear transfer?

Gábor Vajta. The topic of this review is an alternative technique for somatic cell nuclear transfer. Removal of the zona pellucida facilitates manipulations of mammalian oocytes and early embryos, and problems….

Biomechanics approaches to studying human diseases

Gabriel Y.H. Lee, Chwee T. Lim. Nanobiomechanics has recently been identified as an emerging field that can potentially make significant contributions in the study of human diseases. Research into biomechanics at the cellular an….

Wastewater treatment: a model system for microbial ecology

Holger Daims, Michael W. Taylor, Michael Wagner. Biological wastewater treatment is among the most important biotechnological applications and, as drivers of the key processes, microorganisms are central to its success. Therefore, the study of w….

Towards the preparative and large-scale precision manufacture of virus-like particles

Leonard K. Pattenden, Anton P.J. Middelberg, Marcus Niebert, Daniel I. Lipin. Virus-like particles (VLPs) are of interest in vaccination, gene therapy and drug delivery, but their potential has yet to be fully realized. This is because existing laboratory processes, when … Continue reading

A revival of bispecific antibodies

Peter Kufer, Ralf Lutterbüse, Patrick A. Baeuerle. Bispecific antibodies usually do not occur in nature but are constructed by recombinant DNA or cell-fusion technologies. Most are designed to recruit cytotoxic effector cells of the immune system ….

Cre–lox recombination: Cre-ative tools for plant biotechnology

Larry Gilbertson. Targeted insertion and the precise deletion of DNA from transgenic plant chromosomes increase the potential of plant biotechnology for commercial applications and basic research. The Cre–lox

Biological applications of protein transduction technology

Panagiotis S Kabouridis. The impermeable nature of the cell membrane to peptides, proteins, DNA and oligonucleotides limits the therapeutic potential of these biological agents. However, the recent discovery of short cati….